Intracerebroventricular leptin regulates hepatic cholesterol metabolism.
نویسندگان
چکیده
To elucidate the control of hepatic cholesterol metabolism by leptin, rats were administered IV (intravenous) leptin, ICV (intracerebroventricular) leptin or saline. A single low dose of ICV leptin was as effective as a continuous IV infusion of high-dose leptin at decreasing the activities of 3-hydroxy-3-methylglutaryl-CoA reductase and cholesterol 7alpha-hydroxylase. These results indicate that the hepatic response to leptin is transduced via the central nervous system.
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ورودعنوان ژورنال:
- The Biochemical journal
دوره 379 Pt 2 شماره
صفحات -
تاریخ انتشار 2004